[68] “Repurposing a supramolecular iridium catalyst via secondary Zn⋯O=C weak interactions between the ligand and substrate leads to ortho-selective C(sp2)–H borylation of benzamides with unusual kinetics” J. Trouvé, V. Delahaye, M. Tomasini, P. Rajeshwaran, T. Roisnel, A. Poater,* R. Gramage-Doria*  Chem. Sci. 2024, 15, 11794-11806. [link to article]

[67] “Penta- versus hexa-coordinated iridium catalysts control the reactivity of the direct reductive amination between aliphatic amines and aliphatic ketones: a DFT-guided mechanism” H. Lin, L. Li,* L. Liu, Z. Li, T.-M. Nguyen, M. Jouffroy, R. Gramage-Doria*  Catal. Sci. Technol. 2024, 14, 3984-3995. [link to article]

[66] “Cobalt-Catalyzed Wacker-Type Aerobic Oxidation of Olefins into Ketones Enabled by PMHS: Giving Value to a Chemical Waste with Optimal Atom-Economy” N. Abuhafez, R. Gramage-Doria*  ChemCatChem 2024, 16, e202400333. [link to article]

[65] “Shortening C≡N···Br-Csp3 halogen bonds via π-stacking” K. Kupietz, R. N. Gomila, A. Frontera,* R. Gramage-Doria*  CrystEngComm 2024, 26, 2131-2135. [link to article]

[64] “Markovnikov-Selective Cobalt-Catalyzed Wacker-Type Oxidation of Styrenes into Ketones under Ambient Conditions Enabled by Hydrogen Bonding” N. Abuhafez, A. W. Ehlers,* B. de Bruin,* R. Gramage-Doria*  Angew. Chem. Int. Ed. 2024, 63, e202316825. [link to article] Among the most accessed articles in December 2023. Press release by ChemistryViews and CNRS Chimie.

[63] “Carbon-Carbon Bond Forming Reactions in Diazines via Transition Metal-Catalyzed C-H Bond Activation” R. Gramage-Doria,* C. Bruneau, Synthesis 2023, 55, 3470-3486. [link to article]

[62] “A Highly Sterically Congested Bis-Zinc-Porphyrin Containing a Single Buta-1,3-diyne Linkage: From a Serendipitous Finding to Supramolecular Encapsulation” K. Kupietz, J. Trouvé, T. Roisnel, S. Kahlal,* R. Gramage-Doria* Eur. J. Org. Chem. 2023, 26, e202300621. [link to article] Highlighted as Cover article.

[61] “Fast and Selective β‑C−H Borylation of N‑Heterocycles with a Supramolecular Iridium Catalyst: Circumventing Deactivation Pathways and Mechanistic Insights” J. Trouvé, P. Rajeshwaran, M. Tomasini, A. Perennes, T. Roisnel, A. Poater,* R. Gramage-Doria* ACS Catal. 2023, 13, 7715–7729. [link to article]

[60] “Transition Metal-Catalyzed C-H Bond Functionalization of Diazines and Their Benzo Derivatives” C. Bruneau, R. Gramage-Doria in Transition Metal-Catalyzed C-H Functionalization of Heterocycles (Eds. T. Punniyamurthy, A. Kumar). Wiley-VCH, Weinheim, Germany, 2023, pp 393-434. [link to book chapter]

[59] “Catalyst Complexity in a Highly Active and Selective Wacker-Type Markovnikov Oxidation of Olefins with a Bioinspired Iron Complex” J. Trouvé, S. Kasemthaveechok, K. Youssef, R. Gramage-Doria* ACS Catal. 2023, 13, 4421–4432. [link to article]

[58] “Efficient Hydrogen Production at pH 7 in Water with a Heterogeneous Electrocatalyst Based on a Neutral Dimeric Cobalt-Dithiolene Complex” C. Zhang, E. Prignot, O. Jeannin, A. Vacher, D. Dragoe, F. Camerel*, Z. Halime*, R. Gramage-Doria* ACS Catal. 2023, 13, 2367–2373. [link to article] Press release by CNRS.

[57] “Manipulate – techniques to manipulate the surroundings of a synthetic catalyst to control activity and selectivity: general discussion” T. Beweries , M. R. Buchmeiser, N. R. Champness, M. Costas,A. Duhme-Klair,  J. Echeverria, O. Eisenstein, C. T. Ferguson, J. C. Goodall, R. Gramage-Doria, M. Gyton, R. Ham, S. Herrres-Pawlis, C. L. Johnson, P. Kennepohl, B. Lewandowski, P. R. Linnebank, S. A. Macgregor, K. T. Mahmudov, E. Meeus, M. Navarro, P. Ntola, T. N. Parac-Vogt, R. N. Perutz, A. Poater, D. C. Powers, S. Pullen, P. R. Raithby, J. N. H. Reek, I. Riddell, T. R. Ward, A. S. Weller, H. Wennemeres, Faraday Discuss. 2023, 244, 96-118. [link to article]

[56] “Make – underpinning concepts of the synthesis of systems where non-covalent interactions are important: general discussion” T. Beweries , M. R. Buchmeiser, F. E. Bugden, N. R. Champness, B. Chanbasha, M. Costas, J. Echeverria, O. Eisenstein, C. T. Ferguson, J. C. Goodall, R. Gramage-Doria, M. Greenhalgh, M. Gyton, R. Ham, P. Kennepohl, B. Lewandowski, W.-C. Liu, S. A. Macgregor, K. T. Mahmudov, E. Meeus, J. Morris, P. Ntola, T. N. Parac-Vogt, R. N. Perutz, A. Poater, D. C. Powers, P. R. Raithby, J. N. H. Reek, I. Riddell, T. R. Ward, A. S. Weller, H. Wennemeres, Faraday Discuss. 2023, 244, 434-454. [link to article]

[55] “Destabilizing Predictive Copper-Catalyzed Click Reactions by Remote Interactions with a Zinc-Porphyrin Backbone” J. Trouvé, R. Gramage-Doria* Helv. Chim. Acta 2023, 106, e202200191. [link to article]

[54] “Boosting the activity of Mizoroki-Heck cross-coupling reactions with a supramolecular palladium catalyst favoring remote Zn…pyridine interactions” N. Abuhafez, R. Gramage-Doria* Faraday Discuss. 2023, 244, 186-198. [link to article]

[53] “Ruthenium-Catalyzed ortho-C-H Bond Arylation Reactions” C. Bruneau, R. Gramage-Doria in Handbook of CH-Functionalization (Ed. D. Maiti). Wiley-VCH, Weinheim, Germany, 2022. [link to book chapter]

[52] “Divergent behavior in the chemistry of metal-bis(dithiolene) complexes appended with peripheral aliphatic butyl chains” E. Prignot, C. Zhang, O. Jeannin, Z. Halime*, R. Gramage-Doria*, F. Camerel* Eur. J. Inorg. Chem. 2023, 26, e202200591. [link to article]

[51] “Asymmetric Ruthenium Catalysis Enables Fluorophores with Point Chirality Displaying CPL Properties” Y. Sun, K. Dhbaibi, H. Lauwick, C. Lalli, G. Taupier, Y. Molard, R. Gramage-Doria, S. Dérien, J. Crassous*, M. Achard* Chem. Eur. J. 2023, 29, e202203243. [link to article]

[50] “Electronic, steric and catalytic properties of N-heterocyclic carbenerhodium(I) complexes linked to (metallo)porphyrins” L. Poyac, S. Scoditti, X. Dumail, M. Granier, S. Clément, R. Gramage-Doria, C. H. Devillers, S. Richeter* Chem. Commun. 2022, 58, 13270-13273. [link to article]

[49] “Precise Control of the Site-Selectivity in Ruthenium-Catalyzed C-H Bond Amidations by Cyclic Amides as Powerful Directing Groups” Y. Yuan*, Q. Lu, X. Zhu, S. Posada-Pérez, M. Solà, A. Poater*, T. Roisnel and R. Gramage-Doria* Org. Chem. Front. 2023, 10, 42-53. [link to article]

[48] “Iridium-Catalyzed Direct Reductive Amination of Ketones and Secondary Amines: Breaking the Aliphatic Wall”  M. Jouffroy,* Thi-Mo Nguyen, M. Cordier, M. Blot, T. Roisnel, R. Gramage-Doria* Chem. Eur. J. 2022, 28, e202201078. [link to article] Highlighted as Cover Article and Cover Profile.

[47] “Unravelling Enzymatic Features in a Supramolecular Iridium Catalyst by Computational Calculations” M. Tomasini, L. Caporaso, J. Trouvé, J. Poater*, R. Gramage-Doria*, A. Poater* Chem. Eur. J. 2022, 28, e202201970. [link to article]

[46] “Sustainable Wacker-Type Oxidations” P. Rajeshwaran, J. Trouvé, K. Youssef, R. Gramage-Doria* Angew. Chem. Int. Ed. 2022, 61, e202211016. [link to Article]

[45] “Mimicking Enzymes: Taking Advantage of the Substrate-Recognition Properties of Metalloporphyrins in Supramolecular Catalysis” N. Abuhafez , A. Perennes , R. Gramage-Doria* Synthesis 2022, 54, 3473-3481. [link to article]

[44] “Chemical Reactions Controlled by Remote Zn…N Interactions Between Substrates and Catalysts” J. Trouve, R. Gramage-Doria, in Supramolecular Catalysis: New Directions and Developments (Eds.: P. W. N. M. van Leeuwen, M. Raynal), pp 201-209, Wiley-VCH, Weinheim, Germany, 2022. [link to book chapter] 

[43] “Ruthenium-catalysed oxidative coupling of vinyl derivatives and application in tandem hydrogenation” N. Abuhafez, H. Ruffin, R. Kamaraj, C. Bruneau, R. Gramage-Doria* Catal. Sci. Technol. 2021, 11, 5772-5776. [link to article]

[42] “Enzyme-like Supramolecular Iridium Catalysis Enabling C−H Bond Borylation of Pyridines with meta-Selectivity” J. Trouve, P. Zardi, S. Al-Shehimy, T. Roisnel, R. Gramage-Doria* Angew. Chem. Int. Ed. 2021, 60, 18006-18013. [link to article] Highlighted as “Hot Paper”and as Cover article. Press release by CNRS and University of Rennes 1.

[41] “Ultrashort H^δ+⋯H^δ− intermolecular distance in a supramolecular system in the solid state” A. Garcia-Marquez, A. Frontera,* T. Roisnel, R. Gramage-Doria* Chem. Commun. 2021, 57, 7112-7115. [link to article]

[40] “Beyond hydrogen bonding: recent trends of outer sphere interactions in transition metal catalysis” J. Trouve, R. Gramage-Doria* Chem. Soc. Rev. 2021, 50, 3565-3584. [link to article]

[39] “Ruthenium-catalyzed C-H bond functionalization in cascade and one-pot transformations” R. Gramage-Doria*, C. Bruneau* Coord. Chem. Rev. 2021, 428, 21362. [link to article]

[38] “Steering Site-Selectivity in Transition Metal-Catalyzed C-H Bond Functionalization: the Challenge of Benzanilides” R. Gramage-Doria* Chem. Eur. J. 2020, 26, 9688-9709. [link to article]

[37] “Base-controlled product switch in the ruthenium-catalyzed protodecarbonylation of phthalimides: a mechanistic study” M. C. D’Alterio, Y.-C. Yuan, C. Bruneau, G. Talarico, R. Gramage-Doria,* A. Poater* Catal. Sci. Technol. 2020, 10, 180-186. [link to article]

[36] “C-H Bond Alkylation of Cyclic Amides with Maleimides via a Site-Selective-Determining Six-Membered Ruthenacycle” Y.-C. Yuan, M. Goujon, C. Bruneau, T. Roisnel, R. Gramage-Doria*  J. Org. Chem. 2019, 84, 16183-16191. [link to article]

[35] “Site-Selective Ruthenium-Catalyzed C-H Bond Arylations with Boronic Acids: Exploiting Isoindolinones as a Weak Directing Group” Y.-C. Yuan, C. Bruneau, T. Roisnel, R. Gramage-Doria* J. Org. Chem. 2019, 84, 12893-12903. [link to article]

[34] “Site-selective Ru-catalyzed C-H bond alkenylation with biologically relevant isoindolinones: a case of catalyst perfomance controlled by subtle stereo-electronic effects of the weak directing group” Y.-C. Yuan, C. Bruneau, T. Roisnel, R. Gramage-Doria* Catal. Sci. Technol. 2019, 9, 4711-4717. [link to article]

[33] “Ruthenium(II)-catalysed selective C(sp2)-H bond benzoxylation of biologically appealing N-arylisoindolinones” Y.-C. Yuan, C. Bruneau, T. Roisnel, R. Gramage-Doria* Org. Biomol. Chem. 2019, 17, 7517-7525. [link to article]

[32] “Remote Ion-Pair Interactions in Fe-Porphyrin-based Molecular Catalysts for the Hydrogen Evolution Reaction” S. Kasemthaveechok, B. Fabre, G. Loget,* R. Gramage-Doria* Catal. Sci. Technol. 2019, 9, 1301-1308. [link to article]

[31] “Ruthenium-Catalyzed Selective C-H Bond Hydroxylation of Cyclic Imides” Y.-C. Yuan, C. Bruneau, V. Dorcet, T. Roisnel, R. Gramage-Doria* J. Org. Chem. 2019, 84, 1898-1907. [link to article]

[30] “A Supramolecular Palladium Catalyst Displaying Substrate Selectivity by Remote Control” P. Zardi, T. Roisnel, R. Gramage-Doria* Chem. Eur. J. 2019, 25, 627-634. [link to article]

[29] “Merging Transition Metal Catalysis with Phthalimides: a New Entry to Useful Building Blocks” Y.-C. Yuan, C. Bruneau, R. Gramage-Doria* Synthesis, 2018, 50, 4216-4228. [link to article] Invited contribution, Ed: Prof. P. Knochel.

[28] “Ruthenium-catalyzed C-H Bond Heteroarylation of Triazoles Enabled by a Deconvolution Strategy” R. Gramage-Doria,* T. Roisnel Eur. J. Org. Chem. 2018, 6083-6087. [link to article] Highlighted as Cover.

[27] “Ruthenium(II)-Catalyzed C-H (Hetero)Arylation of Alkenylic 1,n-Diazines (n = 2, 3, and 4): Scope, Mechanism, and Application in Tandem Hydrogenations” R. Gramage-Doria,* S. Achelle, C. Bruneau, F. Robin-le Guen, V. Dorcet, T. Roisnel J. Org. Chem. 2018, 83, 1462-1477. [link to article]

 

[26] “Unmasking Amides: Ruthenium-Catalyzed Protodecarbonylation of N‑Substituted Phthalimide Derivatives” Y.-C. Yuan, R. Kamaraj, C. Bruneau, T. Labasque, T. Roisnel, R. Gramage-Doria* Org. Lett. 2017, 19, 6404-6407. [link to article] Highlighted in Organic Chemistry Portal.

[25] “Palladium-Catalysed Cross-Coupling Reactions Controlled by Noncovalent Zn…N Interactions” M. Kadri, J. Hou, V. Dorcet, T. Roisnel, L. Bechki, A. Miloudi, C. Bruneau, R. Gramage-Doria* Chem. Eur. J. 2017, 23, 5033-5043. [link to article] Highlighted as “Hot Paper” and as Cover article. Press release by CNRS and ChemistryViews.

[24] “One-pot Directing Group Formation/C-H Bond Functionalization via Copper(I) and Ruthenium(II) Catalysis” C. Bruneau, R. Gramage-Doria* Adv. Synth. Catal. 2016, 358, 3847-3856. [link to article]

[23] “Nonconventional Supramolecular Self-Assemblies of Zinc(II)-Salphen Building Blocks” T. Groizard, S. Kahlal, V. Dorcet, T. Roisnel, C. Bruneau, J.-F. Halet,* R. Gramage-Doria* Eur. J. Inorg. Chem. 2016, 5143-5151. [link to article]

Mentored publications (Postdoc, PhD and MSc):

[22] “Protonated Bis-1,2,3-triazole as an Anion-Binding Chiral Bronsted Acid for Catalytic Asymmetric Friedel-Crafts Reaction of Indoles with Imines” Y. Furukawa, R. Suzuki, T. Nakashima, R. Gramage-Doria, K. Ohmatsu, T. Ooi* Bull. Chem. Soc. Jpn. 2018, 91, 1252-1257. [link to article]

[21] “Enantioselective Hydroformylation by a Rh-Catalyst Entrapped in a Supramolecular Metallocage” C. García-Simó, R. Gramage-Doria, S. Raoufmoghaddam, T. Parella, M. Costas,* X. Ribas,* J. N. H. Reek* J. Am. Chem. Soc. 2015, 137, 2680-2687. [link to article]

[20] “Transition Metal Catalysis in Confined Spaces” S. H. A. M. Leenders, R. Gramage-Doria, B. de Bruin, J. N. H. Reek* Chem. Soc. Rev. 2015, 44, 433-448. [link to article]

[19] “Gold(I) Catalysis at Extreme Concentrations Inside Self-Assembled Nanospheres” R. Gramage-Doria, J. Hessels, S. H. A. M. Leenders, O. Tröppner, M. Dürr, I. Ivanović-Burmazović, J. N. H. Reek* Angew. Chem. Int. Ed. 2014, 53, 13380-13384. [link to article]

[18] “Phosphinocyclodextrins as Confining Units for Catalytic Metal Centres. Applications to Carbon-Carbon Bond Forming Reactions” M. Jouffroy, R. Gramage-Doria, D. Sémeril, D. Armspach,* D. Matt,* W. Oberhauser, L. Toupet Beilstein J. Org. Chem. 2014, 10, 2388-2405. [link to article]

[17] “Confining Phosphanes Derived from Cyclodextrins for Efficient Regio- and Enantioselective Hydroformylation” M. Jouffroy, R. Gramage-Doria, D. Armspach,* D. Sémeril, W. Oberhauser, D. Matt,* L. Toupet Angew. Chem. Int. Ed. 2014, 53, 3937-3940. [link to article]

[16] “Metallocyclodextrins: Combining Cavitands and Metal Centres” R. Gramage-Doria* ChemistryOpen 2013, 2, 176-179. [link to article]

[15] “New Endeavors in Gold Catalysis – Size Matters” R. Gramage-Doria,* J. N. H. Reek Angew. Chem. Int. Ed. 2013, 52, 13146-13148. [link to article]

[14] “Transition Metal Encapsulation within Supramolecular Diphosphine Capsules” T. Besset, R. Gramage-Doria, J. N. H. Reek* Curr. Org. Chem. 2013, 17, 1489-1498. [link to article]

[13] “Remotely Controlled Iridium-Catalyzed Asymmetric Hydrogenation of Terminal 1,1-Diaryl Alkenes” T. Besset,* R. Gramage-Doria, J. N. H. Reek* Angew. Chem. Int. Ed. 2013, 52, 8795-8797. [link to article]

[12] “Supramolecular Bulky Phosphines Comprising 1,3,5-Triaza-7-phosphaadamantane and Zn(salphen)s: Structural Features and Application in Hydrosilylation Catalysis” D. Anselmo, R. Gramage-Doria, T. Besset, M. V. Escarcega-Bobadilla, G. Salassa, E. C. Escudero-Adan, M. Martinez Belmonte, E. Martin, J. N. H. Reek,* A. W. Kleij* Dalton Trans. 2013, 42, 7595-7603. [link to article]

[11] “Metalated Cavitands (Calixarenes, Resorcinarenes, Cyclodextrins) with Internal Coordination Sites” R. Gramage-Doria,* D. Armspach,* D. Matt* Coord. Chem. Rev. 2013, 257, 776-816. [link to article]

[10] “Organocatalysis in Confined Spaces” R. Gramage-Doria, J. N. H. Reek* ChemCatChem 2013, 5, 677-679. [link to article]

[9] “Supramolecular Ligands in Gold(I) Catalysis” R. Gramage-Doria, R. Bellini, J. Rintjema, J. N. H. Reek* ChemCatChem 2013, 5, 1084-1087. [link to article]

[8] “Chelating Properties of Permethylated 6A,6D-Dideoxy-6A,6D-bis(1-imidazolyl)cyclodextrins Towards Pt(II) and Ru(III)” C. Egloff, R. Gramage-Doria, M. Jouffroy, D. Armspach,* D. Matt,* L. Toupet C. R. Chimie 2013, 16, 509-514. [link to article]

[7] “TRANSDIP: a trans-Chelating Ligand Tailor-Made for Probing Unusual Pd(0) and Pd(II) Intermediates” R. Gramage-Doria, D. Armspach,* D. Matt,* L. Toupet Chem. Eur. J. 2012, 18, 10813-10816. [link to article]

[6] “Non-Conventional Coordination of Cavity-Confined Metal Centres” R. Gramage-Doria, D. Armspach,* D. Matt,* L. Toupet Dalton Trans. 2012, 41, 8786-8796. [link to article]

[5] “Regioselective Opening of Proximally Sulfato-Capped Cyclodextrins” M. Jouffroy, R. Gramage-Doria, D. Armspach,* D. Matt,* L. Toupet Chem. Commun. 2012, 48, 6028-6030. [link to article]

[4] “Catalytic Palladium Phosphination: Modular Synthesis of C1-Symmetric Biaryl-Based Diphosphines” L. Bonnafoux, R. Gramage-Doria, F. Colobert, F. R. Leroux* Chem. Eur. J. 2011, 17, 11008-11016. [link to article]

[3] “Regioselective Double Capping of Cyclodextrin Scaffolds” R. Gramage-Doria, D. Rodriguez-Lucena, D. Armspach,* C. Egloff, M. Jouffroy, D. Matt,* L. Toupet Chem. Eur. J. 2011, 17, 3911-3921. [link to article]

[2] “Ditopic Binding of Cyclodextrin-Included Ligands in Trigonal Silver(I) Complexes” D. Armspach,* D. Matt,* L. Poorters, R. Gramage-Doria, P. Jones, L. Toupet Polyhedron 2011, 30, 573-578. [link to article]

[1] “A Cavity-Shaped Diphosphane Displaying “Oschelating” Behavior” R. Gramage-Doria, D. Armspach,* D. Matt,* L. Toupet Angew. Chem. Int. Ed. 2011, 50, 1554-1559. [link to article]

Patent 1 “Process for preparation of biaryl di- and tri-phosphines as ligands for transition metal-catalyzed asymmetric hydrogenation and coupling reactions by catalytic phosphination of halogenated biaryls” F. R. Leroux, L. Bonnafoux, R. Gramage-Doria, F. Colobert Patent WO 2010-FR52433, FR 2009-58116. [link to article]

Patent 2 “Catalyst for oxidation of alkene into ketone” R. Gramage-Doria, J. Trouve, K. Youssef, S. Kasemthaveechok, Patent WO2024110633, EP4375266. [link to article]